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DTSTART;TZID=America/New_York:20260402T104000
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UID:2253-1775126400-1775129400@biomath.math.ufl.edu
SUMMARY:Erica J. Graham (Bryn Mawr College\, Mathematics)
DESCRIPTION:Modeling GLP-1 Treatments in Ovulatory Dysfunction\nGLP-1 receptor agonists (GLP-1 RAs) have gained widespread attention for their effectiveness in treating metabolic abnormalities such as type 2 diabetes and obesity. Central to their success is the regulation of glucose-insulin metabolism and improvement of insulin resistance. In reproductive endocrinology\, GLP-1 RAs have also shown promise as off-label treatment of polycystic ovary syndrome (PCOS)\, which results from reproductive hormone dysregulation and is often accompanied by insulin resistance. The use of insulin-sensitizing drugs has been a common approach to treating some forms of PCOS\, even though its precise pathogenesis remains unclear. Here we describe a mathematical framework to examine the specific effects of GLP-1 RAs on ovulatory function/defects\, and we discuss the underlying mechanisms that may determine treatment efficacy.
URL:https://biomath.math.ufl.edu/event/erica-j-graham-bryn-mawr-college-mathematics/
LOCATION:Zoom
CATEGORIES:Spring 2026
ATTACH;FMTTYPE=image/jpeg:https://biomath.math.ufl.edu/wp-content/uploads/sites/607/graham_erica.jpg
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DTSTART;TZID=America/New_York:20260409T104000
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UID:2251-1775731200-1775734200@biomath.math.ufl.edu
SUMMARY:Qing Han (Augusta University\, Mathematics)
DESCRIPTION:Pertussis transmission models and demographic shifts under evolving vaccination programs\nPertussis\, a highly contagious infection of the respiratory tract\, was one of the main causes of child morbidity and mortality in developed countries\, in the pre-vaccine era. Following the scale-up and roll-out of childhood vaccination programs in the 1940s–1960s\, the incidence and severity of pertussis decreased drastically. However\, despite high vaccination coverage rates for more than 50 years\, pertussis is still a re-emerging disease requiring novel vaccination strategies taking full consideration of ongoing demographic shifts. Here\, we developed an age-structured transmission dynamics model which allows progressive waning of natural and vaccine-induced immunity\, distinguishes between diagnosed and undiagnosed infections\, and incorporates imported cases and seasonal infections from out-of-province travel. We also developed techniques to calculate key demographic characteristics required in our transmission dynamics model with age stratification guided by the surveillance data\, as well as existing and potential immunization programs. The model was fitted to and validated by the age-stratified pertussis incidence data in the province of Ontario\, Canada\, and the simulation based on the validated model shows a case distribution shift from adolescents to infants until 2050\, and calls for additional boosting immunizations in the province. The fundamental platforms and modeling techniques in this study are suitable for use to assess any other immunization programs for childhood diseases elsewhere.
URL:https://biomath.math.ufl.edu/event/qing-han-augusta-university-mathematics/
LOCATION:Zoom
CATEGORIES:Spring 2026
ATTACH;FMTTYPE=image/jpeg:https://biomath.math.ufl.edu/wp-content/uploads/sites/607/han_qing.jpeg
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