Network Architecture Dictates Dynamics: Operating Principles of Interconnected Feedback Loops in Cell Fate Transitions

Interconnected feedback loops are prevalent in cell fate transitions, yet their operating principles remain largely unexplored. In this talk, we will examine high-dimensional feedback loops (HDFLs) organized into serial, hub, and cyclic network architectures. We will see that network architecture dictates the accessible phenotype space: high-centrality hub networks robustly restrict dynamics to bistability, whereas lower-centrality serial and cyclic networks support higher-dimensional state spaces.