Spatial and temporal dynamics of dengue in southeast Asia

Dengue viruses exist as four antigenically distinct serotypes DENV1-DENV4 that interact with each other in multiple immune-mediated mechanisms.  One of these mechanisms, immune-mediated enhancement, through which immunity derived from one serotype leads to either enhanced disease or enhanced viral replication of subsequent infections, has been the focus of considerable study. In this presentation, I will describe the work of our group to characterize the dynamic impact of immune enhancement, the potential impact of this on vaccine design, use and evaluation and the impact of immune enhancement on spatial temporal dynamics.