On the principle of host evolution in host-pathogen interactions We use a two-host one pathogen immuno-epidemiological model to argue that the principle for host evolution, when the host is subjected to a fatal disease, is minimization of the case fatality proportion F. This principle is valid whether the disease is chronic or leads to recovery. In …

Carcinogenesis The multistage model for carcinogenesis was developed in the 1950’s.  The model is largely attributed to Armitage and Doll in a 1954 paper in the British Journal of Cancer.  There were some follow-up articles in the next couple of decades expanding on the mathematics of this theory.  However, after that there was a fallow …