Mathematical modelling of the transmission dynamics of opisthrochiasis The trematode liver fluke (flat worm), Opisthorchis viverrini, is prevalent in southeast Asia, causing the chronic hepatobiliary disease, opisthorchiasis. Long term infection can lead to the bile duct cancer, cholangiocarcinoma, which is typically fatal. We develop an ordinary differential equation (ODE) model of the transmission dynamics of …

The effect of myeloid-derived suppressor cells on glioblastoma-immune dynamics Despite improvements in cancer therapies, the current standard of care for glioblastoma (GBM) only confers a 5.1% five-year survival rate. A major reason for this poor prognosis is the brain cancer’s highly complex and immunosuppressive tumor microenvironment, thus pointing researchers to novel immunotherapies. This talk seeks …

Statistical Adjustment for Reporting Bias in Surveillance Data of Infectious Diseases Reporting bias is common in the surveillance of infectious diseases and takes different forms. A typical example is that outbreaks are investigated only if the number of cases exceeds a prespecified threshold. Another example is that most outbreak investigations only survey cases, ignoring individuals …