Mathematical Biology

Integrative disease-drug-trial platform for Parkinson’s disease Despite the wide research on Parkinson’s disease (PD), current knowledge on how to link pathophysiological changes and clinical symptoms is still minimal. We are developing an integrative disease-drug-trial platform using different analysis approaches that serves as a quantitative link between (potential) biomarkers of disease progression and clinical scores. This

Rich and realistic dynamics of resource quality based population models All organisms are composed of multiple chemical elements such as nitrogen (N), phosphorus (P), and carbon (C). P is essential to build nucleic acids (DNA and RNA) and N is needed for protein production. To keep track of the mismatch between P requirement in the

Models of Vimentin Organization Under Actin-Driven Transport Intermediate filaments form an essential structural network, spread throughout the cytoplasm, and play a key role in cell mechanics, intracellular organization and molecular signaling. The maintenance of the network and its adaptation to the cell's dynamic behavior relies on several mechanisms implicating cytoskeletal crosstalk which are not fully