Cell packing in the notochord: morphometry, pattern, and forces The notochord, the defining feature of chordates, is a pressurized tube which actuates elongation of the chordate embryo. The zebrafish notochord …
Understanding Microvascular Growth through Experimental and Computational Modelling Understanding microvascular growth, similar to other physiological processes, requires identifying multiple cell, system, and environmental interactions. A challenge is identifying such dynamics …
Models of Vimentin Organization Under Actin-Driven Transport Intermediate filaments form an essential structural network, spread throughout the cytoplasm, and play a key role in cell mechanics, intracellular organization and molecular …
Rich and realistic dynamics of resource quality based population models All organisms are composed of multiple chemical elements such as nitrogen (N), phosphorus (P), and carbon (C). P is essential …
Integrative disease-drug-trial platform for Parkinson’s disease Despite the wide research on Parkinson’s disease (PD), current knowledge on how to link pathophysiological changes and clinical symptoms is still minimal. We are …
Modeling Resistance in Oncolytic Viral Therapy Drug resistance is a common phenomenon in the treatment of cancer. As with other cancer therapies, treatment failure due to resistance also occurs for …
Structural and practical identifiability analysis of a multiscale immuno-epidemiological model We perform the identifiability analysis of a multiscale model of seasonal influenza with multiscale data. We show that the well …
Collective Cell Behavior in 3D Cell Assemblies—3D Printed Structures, Random Aggregates, and Perfectly Precise Arrays The remarkable differences between cells grown on plates and cells in vivo or 3D culture …
Multi-Scale Models of Infectious Disease Dynamics and Validating with Data The bidirectional feedback induced through population and individual-level infectious disease and host immune dynamics requires development of innovative multi-scale models. …
Modelling Microtube Driven Invasion of Glioma Malignant gliomas are highly invasive brain tumors. Recent attention has focused on their capacity for network-driven invasion, whereby mitotic events can be followed by …
