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Mathematical modelling of malaria: Population-scale dynamics, vaccination, and evolution Malaria transmission and persistence depend critically on the interaction between parasite dynamics, human immunity, and epidemiological feedbacks. I will review recent work with collaborators developing and analysing structured PDE models spanning both population and within-host scales. At the population level, we couple vector–host epidemiology with the … |
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Mechanistic Insights Into Parkinson’s Disease and Sex Differences in Liver Oxidative Stress In volume transmission, or neuromodulation, neurons communicate not through direct, one-to-one synaptic connections, but by releasing neurotransmitters broadly into the extracellular space from numerous varicosities. This type of signaling is particularly relevant for serotonin and dopamine neurons, which project from the dorsal raphe … |
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Engineering ovarian cancer solutions using evolutionary medicine, math modeling, and big data Ovarian cancer is the most lethal gynecologic cancer despite the progress we’ve made in personalized medicine; there has only been modest survival gains for ovarian cancer patients with over 80% of patients experiencing recurrent disease. Furthermore, many current clinical trials often fail to … |
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Adaptive Dynamics on High-Dimensional Optimization Random Landscapes What do spin glasses (a subfield of high-dimensional probability and statistical physics), evolutionary biology, and artificial intelligence (AI) have in common? All involve optimization on rugged landscapes where metastable states pose significant challenges to the search for optima. In this talk, I will discuss an example of such … |
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